ENT domain (IPR005491)

Short name: ENT_dom

Overlapping homologous superfamilies

Domain relationships



The EMSY N-terminal (ENT) domain is a ~90-residue module, which is unique in the human proteome, although multiple copies are found in Arabidopsis proteins. In the plant proteins, the ENT domains are accompanied by Agenet domains, plant specific homologues of Tudor domains [PMID: 14651845, PMID: 12575993].

The ENT domain consists of a unique arrangement of five alpha-helices that fold into a helical bundle arrangement. Overall, the three-dimensional structure adopts a club-like shape that consists of an extended N-terminal alpha-helix that connects to a helical bundle substructure. The ENT domain forms a homodimer via the anti-parallel packing of the long N-terminal alpha-helix from each subunit [PMID: 15978617, PMID: 15947784].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles