Conserved Site

Glucokinase regulatory protein, conserved site (IPR005486)

Short name: Glucokinase_regulatory_CS


The glucokinase regulatory protein (GCKR) [PMID: 7925465] is a vertebrate protein that inhibits glucokinase by forming a complex with the enzyme, which plays a role in the control of blood glucose homeostasis. GCKR is a protein of about 70 Kd which is evolutionary related to bacterial N-acetylmuramic acid 6-phosphate etherases (MurNAc-6-P etherase, murQ), which are about half the size of GCKR and form active homodimers. MurNAc-6-P etherases catalyse the cleavage of the D-lactyl ether substituent of the bacterial cell wall sugar MurNAc and play a role in recycling of the cell wall [PMID: 18049859]. The 3D structure of the Haemophilus influenzae HI0754/murQ protein shows structural relationships with other sugar isomerase (SIS) domain proteins. In contrast to mono-SIS bacterial MurNAc-6-P etherase, mammalian GCKR is composed of two SIS domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns