Family

Profilin (IPR005455)

Short name: PFN

Overlapping homologous superfamilies

Family relationships

Description

This entry represents the Profilin family, which are small eukaryotic proteins that have different functions. In plants, they are major allergens present in pollens [PMID: 21458043].

The majority of the Profilin family members binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation [PMID: 16542844]. However, some Profilin family members, such as Profilin4 from mammals, does not binds to actin and may have functions distinct from regulating actin dynamics [PMID: 19419568]. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain [PMID: 11137023]. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway [PMID: 7945274,PMID: 1651167].

Some Profilins can also bind to polyphosphoinositides such as PIP2 [PMID: 11034907]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
PRINTS
Pfam
CDD
SMART
PANTHER