Family

Profilin (IPR005455)

Short name: PFN

Family relationships

Description

This entry represents the Profilin family, which are small eukaryotic proteins that have different functions. In plants, they are major allergens present in pollens [PMID: 21458043].

The majority of the Profilin family members binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation [PMID: 16542844]. However, some Profilin family members, such as Profilin4 from mammals, does not binds to actin and may have functions distinct from regulating actin dynamics [PMID: 19419568].

Some Profilins can also bind to polyphosphoinositides such as PIP2 [PMID: 11034907]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
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