Profilin1/2/3, vertebrate (IPR005454)

Short name: Profilin1/2/3_vertebrate

Overlapping homologous superfamilies

Family relationships


This entry represents Profilin1/2/3 (PFN1-3) from vertebrates.

So far, four Profilins have been identified in mammals, PFN1-4. PFN1-3 contain an actin-binding site and a poly-L-proline binding site, while PFN4 lost both [PMID: 19419568]. This entry includes PFN1-3 that bind to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation [PMID: 16542844].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.