Lysosome membrane protein II (IPR005429)

Short name: LimpII

Overlapping homologous superfamilies


Family relationships

  • CD36 family (IPR002159)
    • Lysosome membrane protein II (IPR005429)


Lysosome membrane protein II (LIMP II) is a 478-residue glycoprotein expressed in the membrane of lysosomes and secretory granules with lysosomal properties [PMID: 1715871]. The N-terminal segment (residues ~4-26) constitutes an uncleavable signal peptide [PMID: 1715871]. LIMP II possesses an additional C-terminal hydrophobic region that, together with the signal peptide, may anchor the protein to the membrane [PMID: 1715871]. The major portion of the protein resides on the luminal side and contains 11 potential N-glycosylation sites and 5 cysteine residues. The N- and C-terminal ends of the protein constitute short cytoplasmic tails. LIMP II is a subgroup of a larger family of the cell surface protein CD36 involved in cell adhesion.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005044 scavenger receptor activity

Cellular Component

GO:0005764 lysosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.