Nucleolar complex protein 2 (IPR005343)

Short name: Noc2

Overlapping homologous superfamilies


Family relationships



In Saccharomyces cerevisiae, Noc2 forms a nucleolar complex with Mak21 that binds to 90S and 66S pre-ribosomes. It also forms a nuclear complex with Noc3 that binds to 66S pre-ribosomes [PMID: 11371346]. Both complexes mediate intranuclear transport of ribosomal precursors [PMID: 11371346].

In humans, Noc2 (also known as NIR) acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. It also acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis [PMID: 16322561, PMID: 20123734, PMID: 20959462].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.