Transcription factor, TCP (IPR005333)

Short name: Transcription_factor_TCP

Overlapping homologous superfamilies


Family relationships



The TCP transcription factor family was named after: teosinte branched 1 (tb1, Zea mays (Maize)) [PMID: 17452340], cycloidea (cyc) (Antirrhinum majus) (Garden snapdragon) [PMID: 10363373] and PCF in rice (Oryza sativa) [PMID: 12000681, PMID: 539398]. The TCP proteins code for structurally related proteins implicated in the evolution of key morphological traits [PMID: 10363373]. However, the biochemical function of CYC and TB1 proteins remains to be demonstrated. One of the conserved regions is predicted to form a non-canonical basic-Helix-Loop-Helix (bHLP) structure. This domain is also found in two rice DNA-binding proteins, PCF1 and PCF2, where it has been shown to be involved in DNA-binding and dimerization.

This family of transcription factors are exclusive to higher plants. They can be divided into two groups, TCP-C and TCP-P, that appear to have separated following an early gene duplication event [PMID: 17568984]. This duplication event may have led to functional divergence and it has been proposed that that the TCP-P subfamily are transcriptional repressors, while the TPC-C subfamily are transcription activators [PMID: 16123132].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.