Family

Mob1/phocein (IPR005301)

Short name: Mob1_phocein

Family relationships

None.

Description

Mob1 is an essential Saccharomyces cerevisiae (Baker's yeast) protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [PMID: 9436989]. This family also includes phocein Q9QYW3, a rat protein that by yeast two hybrid interacts with striatin [PMID: 11251078].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D
PANTHER
Pfam