Family

Peroxysomal long chain fatty acyl transporter (IPR005283)

Short name: FA_transporter

Overlapping homologous superfamilies

None.

Family relationships

Description

Eukaryotic ABC transporters are found either as complete transporters or as half transporters, which dimerise to form an active transporter. Four half ABC transporter proteins have been identified in the human peroxisome membrane: the 70 kDa peroxisomal membrane protein (PMP70), the adrenoleukodystrophy protein (ALDP), the PMP70-related protein (P70R) and the ALDP-related protein (ALDR) [PMID: 11248239]. This entry includes PMP70 [PMID: 1301993, PMID: 11883951] (renamed as ATP-binding cassette sub-family D member 3, ABCD3) and ALDP [PMID: 8441467, PMID: 18757502] (ATP-binding cassette sub-family D member 1, ABCD1) from human, and yeast peroxisomal long-chain fatty acid import proteins PAT1 (PXA2) and PAT2 (PXA1) [PMID: 8670886].

The members of this family are involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.

GO terms

Biological Process

GO:0015910 peroxisomal long-chain fatty acid import

Molecular Function

GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0005324 long-chain fatty acid transporter activity

Cellular Component

GO:0016021 integral component of membrane
GO:0005777 peroxisome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs