Homoserine kinase, type II (IPR005280)

Short name: Homoserine_kinase_II

Overlapping homologous superfamilies

Family relationships



This family is composed of unusual homoserine kinases, from a subset of bacteria, which have a protein kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases (see IPR000870) present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K) [PMID: 10589737].

GO terms

Biological Process

GO:0009088 threonine biosynthetic process

Molecular Function

GO:0004413 homoserine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.