Dipeptide/tripeptide permease (IPR005279)

Short name: Dipep/tripep_permease

Overlapping homologous superfamilies


Family relationships


This entry includes dipeptide and tripeptide transporters belonging to the proton-dependent oligopeptide transporter (POT) family, also called the peptide transport (PTR) family.

The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transporters found in a number of organisms as diverse as bacteria and humans. The amino acid/peptide transporter family of proteins is distinct from the ABC-type peptide transporters and was uncovered by sequence analysis of a number of recently discovered peptide transport proteins [PMID: 7476181]. This family consists of bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists.

GO terms

Biological Process

GO:0015833 peptide transport

Molecular Function

GO:0015197 peptide transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.