Family

PdxA family (IPR005255)

Short name: PdxA_fam

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry represents the PdxA family. PdxA is an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC:1.1.1.262) active in pyridoxal phosphate biosynthesis [PMID: 12896974]. PdxA2, a functional paralogue of PdxA, catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). It can also use D-threonate 4-phosphate as substrate [PMID: 27294475, PMID: 27402745]. This family also includes TphB, involved in terephthalate degradation [PMID: 16517628].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0051287 NAD binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam
TIGRFAMs