Family

ComB-like (IPR005238)

Short name: ComB-like

Family relationships

Description

2-phosphosulpholactate phosphatase (ComB; EC:3.1.3.71) is a magnesium-dependent acid phosphatase that catalyzes the second step in coenzyme M (CoM; 2-mercaptoethanesulphonic acid) biosynthesis, namely, the hydrolysis of (2R)-2-phospho-3-sulpholactate to yield (2R)-3-sulpholactate and phosphate. CoM is an essential cofactor that acts as the terminal methyl carrier in methanogenesis [PMID: 11589710]. CoM has also a role in the bacterial pathway of aliphatic epoxide carboxylation [PMID: 10411892]. Homologues of ComB have been identified in all available cyanobacterial genome sequences and in genomes from phylogenetically diverse bacteria and archaea. However, many of these organisms lack homologues of other CoM biosynthetic genes.

ComB has a complex alpha/beta topology. The monomer is composed of two domains thought to be related by a common ancestral gene, plus a C-terminal helical and beta-hairpin region [PMID: 16927339].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0050532 2-phosphosulfolactate phosphatase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY
Pfam