Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase LarE (IPR005232)

Short name: LarE

Overlapping homologous superfamilies

Family relationships



This family includes LarE, one of three accessory proteins (the others being LarB and LarC) present in the lactate racemization operon larA-E. LarA is a nickel-dependent lactate racemase, and the accessory proteins are required for the incorporation of Ni in the lactate racemase apoprotein [PMID: 24710389]. The accessory proteins LarB, LarC, and LarE are widely distributed in microorganisms. Among them, LarC and LarE have been found to be Ni-containing proteins [PMID: 24710389].

In Lactobacillus plantarum, LarE catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN) [PMID: 27114550].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016783 sulfurtransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.