Pheromone shutdown, TraB, bacterial/archaeal (IPR005230)

Short name: Pheromone_shutdown_TraB_bac

Overlapping homologous superfamilies


Family relationships

  • TraB family (IPR002816)
    • Pheromone shutdown, TraB, bacterial/archaeal (IPR005230)


In prokaryotes, for example Enterococcus faecalis (Streptococcus faecalis), the conjugative transfer of certain plasmids is controlled by peptide pheromones [PMID: 15374642]. Plasmid free recipient cells secret plasmid specific oligopeptides, termed sex pheromones. They induce bacterial clumping and specifically activate the conjugative transfer of the corresponding plasmid. Once recipient cells acquire the plasmid they start to produce a pheromone inhibitor to block the activity of the pheromone and to prevent plasmid containing cells from clumping; they also become donor cells able to transfer the plasmid to plasmid free recipient cells. Examples of such plasmid-pheromone systems are bacteriocin plasmid pPD1 [PMID: 7559344], haemolysin/bacteriocin plasmid, pAD1 [PMID: 1924555], tetracycline-resistance plasmid, pCF10 [PMID: 8349565], and the haemolysin/bacteriocin plasmid, pOB1 [PMID: 7772836].

TraB in combination with another factor contributes to pheromone shutdown in cells that have acquired a plasmid. It exact function has not yet been determined [PMID: 2158976, PMID: 10850999].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.