Endo-1,3(4)-beta-glucanase (IPR005200)

Short name: Endo-beta-glucanase

Overlapping homologous superfamilies


Family relationships



This is a family of beta-1,3(4)-glucanases belonging to glycoside hydrolase family 81 (GH81). Proteins in this entry include fission yeast Eng1/Eng2 and budding yeast Dse4 (also known as Eng1) and Acf2. They have been shown to hydrolyse linear beta-1,3-glucan chains [PMID: 17933563]. Eng1 is required for the degradation of the primary septum after completion of cytokinesis [PMID: 12665550, PMID: 12455695]. Eng2 may couple the endocytic coat to the actin module [PMID: 25040903]. This entry also includes some uncharacterised proteins from plants and bacteria.

O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0052861 glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.