Potentiating neddylation domain (IPR005176)

Short name: PONY_dom

Overlapping homologous superfamilies


Domain relationships



This domain is found in the eukaryotic family defective in cullin neddylation, which includes DCN1 and DCN1-like proteins. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [PMID: 15988528, PMID: 18826954].

The structure of this domain is composed entirely of alpha helices [PMID: 17597076, PMID: 18206966]. It has been referred to as potentiating neddylation domain (PONY) and can be found in association with an N-terminal UBA domain. The PONY domain contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [PMID: 18206966].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles