Domain

Ku70/Ku80, N-terminal alpha/beta (IPR005161)

Short name: Ku_N

Domain relationships

None.

Description

The Ku heterodimer (composed of Ku70 P12956 and Ku80 P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the N-terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold [PMID: 10191092].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam