Domain

Ku70/Ku80 C-terminal arm (IPR005160)

Short name: Ku_C

Domain relationships

None.

Description

The Ku heterodimer (composed of Ku70 P12956 and Ku80 P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C-terminal arm. This alpha helical region embraces the beta-barrel domain IPR006164 of the opposite subunit [PMID: 11493912].

GO terms

Biological Process

GO:0006303 double-strand break repair via nonhomologous end joining

Molecular Function

GO:0004003 ATP-dependent DNA helicase activity
GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam