ArgK protein (IPR005129)

Short name: ArgK

Family relationships



YgfD was first identified as an ATPase, ArgK, which appeared to phosphorylate the periplasmic binding proteins of the lysine, arginine, ornithine (LAO) transport system, as well as the arginine, ornithine transport system [PMID: 2136858]. Bacterial periplasmic transport systems require the function of a specific substrate-binding protein, located in the periplasm, and several cytoplasmic membrane transport components. In Escherichia coli, the arginine-ornithine transport system requires an arginine-ornithine-binding protein and the lysine-arginine-ornithine (LAO) transport system includes a LAO-binding protein. Both periplasmic proteins were shown to be phosphorylated by ArgK [PMID: 2136858], resulting in reduced levels of transport activity.

However, another study showed that the kinase activity of ArgK did not affect transport activity [PMID: 9733684]. Furthermore, neither the molecular weight nor the pI of ArgK are similar to that of the protein kinase that was purified based on its activity [PMID: 2104851]. YgfK has been identified as part of an operon that encodes enzymes converting succinate to propionate [PMID: 18950999]. YgfD was confirmed to have GTPase activity, but no function could be assigned to it. The function of ArgK remains unclear.

This entry represents ArgK and other proteins of the ArgK family. It includes methylmalonic aciduria type A protein, which may have GTPase and ATPase activity and function as chaperone. In Caenorhabditis elegans, this protein is likely to have a role in propionyl-CoA metabolism and adenosylcobalamin synthesis [PMID: 16843692].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.