Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding (IPR005121)

Short name: PheS_beta_Fdx_antiC-bd

Domain relationships



Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in the translation of the genetic code by means of covalent attachment of amino acids to their cognate tRNAs. Phenylalanine-tRNA synthetase (PheRS, also known as Phenylalanine-tRNA ligase) is known to be among the most complex enzymes of the aaRS family. Bacterial and mitochondrial PheRSs share a ferredoxin-fold anticodon binding (FDX-ACB) domain, which represents a canonical double split alpha+beta motif having no insertions. The FDX-ACB domain displays a typical RNA recognition fold (RRM) (see PDOC00030) formed by the four-stranded antiparallel beta sheet, with two helices packed against it [PMID: 7664121, PMID: 9016717, PMID: 10049785, PMID: 12962494, PMID: 18611382].

GO terms

Biological Process

GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0008033 tRNA processing

Molecular Function

GO:0005524 ATP binding
GO:0000287 magnesium ion binding
GO:0004826 phenylalanine-tRNA ligase activity
GO:0000049 tRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles