Transcription-repair-coupling factor, C-terminal domain (IPR005118)

Short name: TRCF_C

Overlapping homologous superfamilies

Domain relationships



This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.

The C-terminal region of TRCF have been shown to be necessary for RNAP displacement [PMID: 7876261, PMID: 14602898].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.