Domain

Saccharopine dehydrogenase, NADP binding domain (IPR005097)

Short name: Sacchrp_dh_NADP

Domain relationships

Description

This entry represents the NADP binding domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase [PMID: 11080625, PMID: 11354603].

Saccharopine dehydrogenase (EC:1.5.1.10) catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine [PMID: 19449898]. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase. Saccharopine is an intermediate in lysine metabolism.

Homospermidine synthase (HSS) (EC:2.5.1.44) catalyses the synthesis of the polyamine homospermidine from 2 putrescine molecules in an NAD+-dependent reaction [PMID: 8841401]. HSS evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase [PMID: 19196710, PMID: 20194510] and the structure of HSS is related to lysine metabolic enzymes [PMID: 20194510].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam