Domain

Exportin-2, C-terminal (IPR005043)

Short name: XPO2_C

Overlapping homologous superfamilies

Domain relationships

None.

Description

Exportin-2, also known as CAS, is an export receptor for importin-alpha [PMID: 9323134]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [PMID: 10394916].

This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [PMID: 15602554].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008536 Ran GTPase binding
GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam