Serine incorporator/TMS membrane protein (IPR005016)

Short name: TDE1/TMS

Overlapping homologous superfamilies


Family relationships


The serine incorporator/TMS membrane protein (TDE1/TMS) family include SERINC1-5 from mammals and membrane protein Tms1 from budding yeasts. Members in this family contain eleven transmembrane helices.

SERINC1-5 function in incorporating serine into membranes and facilitating the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids [PMID: 16120614]. Serinc3 (also known as TDE1) is overexpressed in tumours [PMID: 16547497].

The function of Tms1 is not clear.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.