Domain

mRNA (guanine-N(7))-methyltransferase domain (IPR004971)

Short name: mRNA_G-N7_MeTrfase_dom

Domain relationships

Description

This entry represents mRNA (guanine-N(7))-methyltransferase, which can either be found as a single domain protein, or as a domain within the mRNA-capping enzyme catalytic subunit.

mRNA (guanine-N(7))-methyltransferase methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA containing 5'-terminal GpppC [PMID: 10679253, PMID: 7623811, PMID: 9790902, PMID: 9705270, PMID: 10347220, PMID: 22099306]. Viral mRNA capping enzymes, meanwhile, are multidomain proteins that catalyse the first two reactions in the mRNA cap formation pathway. They are heterodimers consisting of a large (catalytic) and small subunit.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam