Nucleoside-triphosphatase, THEP1 type (IPR004948)

Short name: Nuc-triphosphatase_THEP1

Overlapping homologous superfamilies

Family relationships



This entry represents a family of nucleoside-triphosphatases which have activity towards ATP, GTP, CTP, TTP and UTP and may hydrolyse nucleoside diphosphates with lower efficiency [PMID: 17291528]. It includes proteins from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [PMID: 14503925]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [PMID: 15777481]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [PMID: 17291528].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0098519 nucleotide phosphatase activity, acting on free nucleotides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.