Family

Nucleoside-triphosphatase, THEP1 type (IPR004948)

Short name: Nuc-triphosphatase_THEP1

Family relationships

None.

Description

This entry represents a family of nucleoside-triphosphatases which have activity towards ATP, GTP, CTP, TTP and UTP and may hydrolyse nucleoside diphosphates with lower efficiency [PMID: 17291528]. It includes proteins from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [PMID: 14503925]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [PMID: 15777481]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [PMID: 17291528].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0098519 nucleotide phosphatase activity, acting on free nucleotides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
Pfam