Tropomodulin (IPR004934)

Short name: TMOD

Overlapping homologous superfamilies


Family relationships


Actin filaments have an intrinsic polarity, each with a fast-growing (barbed) end and a slow-growing (pointed) end. The slow-growing end is regulated by tropomodulins, a family of capping proteins that require tropomyosins for optimal function [PMID: 19216712]. Tropomyosins contains two domains: an N-terminal unstructured tropomyosin-binding region which has an actin pointed-end-capping activity, an C-terminal region that contains one compact domain represented by alternating alpha-helices and beta-structures [PMID: 19216712]. The tropomyosin-independent actin-capping site is located at the C terminus [PMID: 19216712]. The structure of tropomyosin-1 has been solved [PMID: 25061212].

Proteins in this entry include Tropomodulin (TMOD)-1/2/3/4 and Leiomodin (LMOD)-1/2/3.

GO terms

Biological Process

GO:0051694 pointed-end actin filament capping

Molecular Function

GO:0005523 tropomyosin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.