Iron permease FTR1/Fip1/EfeU (IPR004923)

Short name: FTR1/Fip1/EfeU

Overlapping homologous superfamilies


Family relationships


Fungi uptake extracellular ferrous iron (Fe2+) using a bipartite high-affinity transporter consisting of a multicopper ferroxidase associated with a membrane permease which translocates generated ferric iron (Fe3+) into the cytosol. The Saccharomyces cerevisiae (Baker's yeast) iron permease FTR1 is a plasma membrane permease for high-affinity iron uptake [PMID: 8599111]. FTR1, together with multicopper oxidase FET3, mediate high-affinity iron uptake. Schizosaccharomyces pombe Fio1 (ferrous iron oxidase) and Fip1 (ferriferous permease), share significant similarity to FET3 and FTR1 from S. cerevisiae [PMID: 8995275].

Many bacteria possess Fe2+ transporters with functional similarities to the FET3-FTR1 system. Escherichia coli encodes an EfeUOB transporter where EfeU is homologous to the high-affinity iron permease FTR1 of Saccharomyces cerevisiae [PMID: 16987175, PMID: 17627767]. Bacillus subtilis encodes similar proteins, but not identical to the E. coli EfeUOB transporter components. B. subtilis EfeUOB uses a transport system that permits the high-affinity acquisition of both Fe2+ and Fe3+ [PMID: 23764491].

This entry also includes the vacuolar iron transporter FTH1 [PMID: 10608875].

GO terms

Biological Process

GO:0034755 iron ion transmembrane transport

Molecular Function

GO:0005381 iron ion transmembrane transporter activity

Cellular Component

GO:0033573 high-affinity iron permease complex
GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.