Gamma interferon inducible lysosomal thiol reductase GILT (IPR004911)

Short name: Interferon-induced_GILT

Overlapping homologous superfamilies


Family relationships



In humans, GILT (gamma-interferon-inducible lysosomal thiol reductase) functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation [PMID: 23246037, PMID: 21506690]. Several other functions of GILT have also been found, for instance, GILT can act as a host factor for Listeria monocytogenes infection and is involved in the maintenance of cellular glutathione (GSH) levels [PMID: 23246037].

GILT is characterised by a CXXC motif in the active site and an enzymatic mechanism in which the pair of active site cysteine residues cooperate to reduce substrate disulfide bonds [PMID: 23246037]. The GIL homologues from Drosophila melanogaster may play a role in the innate immune response upon bacterial challenge [PMID: 24491521].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.