Domain

Yippee/Mis18/Cereblon (IPR004910)

Short name: Yippee/Mis18/Cereblon

Overlapping homologous superfamilies

None.

Domain relationships

Description

This domain is found in both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins [PMID: 11240639]. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A [PMID: 17199038, PMID: 22264723]. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus [PMID: 22552327]. This domain includes the CULT domain from proteins such as Cereblon [PMID: 25569776].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam