H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminal (IPR004889)

Short name: HMD_C

Domain relationships



This entry represents the C-terminal domain of H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenases. The N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase system of methanogenic archaea is composed of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd, represented by this entry) and F420-dependent methylenetetrahydromethanopterin dehydrogenase (IPR002844) [PMID: 8215796, PMID: 9151968]. Hmd is an iron-sulphur-cluster-free enzyme that contains an intrinsic CO ligand bound to iron [PMID: 15506791]. This domain is found at the C terminus of two distinct subgroups: one has been experimentally characterised as H2-forming N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase (Hmd or HmdI), and the other one contains isozymes that have not been experimentally characterised (HmdII and HmdIII). Because all three isozyme forms are present in each of the corresponding sequenced genomes, it has been suggested that HmdII and HmdIII may not exhibit Hmd activity and may have a different biological function [PMID: 11081790].

GO terms

Biological Process

GO:0015948 methanogenesis
GO:0055114 oxidation-reduction process

Molecular Function

GO:0047068 N5,N10-methenyltetrahydromethanopterin hydrogenase activity
GO:0018537 coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.