HSR domain (IPR004865)

Short name: HSR_dom

Overlapping homologous superfamilies


Domain relationships



The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerisation domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) [PMID: 10212234]. This domain can also be found in Vertebrate AutoImmune REgulator (AIRE) protein, a transcription regulator predominantly expressed in thymus medullary epithelial cells which also localises to nuclear dots [PMID: 24275490].

The HSR domain, which has also been named ASS (AIRE, Sp-100 and Sp140) domain [PMID: 10049735], can be found alone or in association with other domains, such as SAND IPR000770, PHD finger IPR019787 and Bromo IPR001487, The HSR domain is predicted to be predominantly alpha-helical [PMID: 9697411, PMID: 10212234, PMID: 10049735].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles