6-phosphogluconate dehydrogenase, YqeC-type (IPR004849)

Short name: 6DGDH_YqeC

Overlapping homologous superfamilies


Family relationships


Bacillus subtilis contains three classes of 6-phosphogluconate dehydrogenases (6PGD), including Gnd (YqjI), GntZ and YqeC. This entry represent the YqeC class, which in B. subtilis is a truncated 6PGD that possesses a NAD+-dependent activity [PMID: 15231785].

YgeC class of 6PGD includes prokaryotic proteins similar to the bacterial and eukaryotic 6PGD but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. This truncated 6PGD can be found in most Gram-positive organisms, such as Bacillus subtilis and Mycobacterium tuberculosis. The protein from Methylobacillus flagellatus KT has been characterised as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle [PMID: 10658669]. This entry also includes Pseudomonas fluorescens 6PGD, which is active with either NAD+ and NADP+ [PMID: 6402366], and Streptomyces and heterofermentative lactic acid bacteria 6PGD, which has the NAD+-dependent activity [PMID: 3208200, PMID: 8829540].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.