SLC12A transporter family (IPR004842)

Short name: SLC12A_fam

Overlapping homologous superfamilies


Family relationships


This is a family of K-Cl cotransporters. It includes bumetanide-sensitive sodium-(potassium)-chloride cotransporter, an electrically silent transporter system which is a mediator of sodium and chloride reabsorption. It plays a vital role in the regulation of ionic balance and cell volume. Bumetanide-sensitive sodium-(potassium)-chloride cotransporter belongs to the SLC12A family of transporters.

GO terms

Biological Process

GO:0006811 ion transport

Molecular Function

GO:0015377 cation:chloride symporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.