Two related oncogenes, TCL-1 P56279 and MTCP-1 P56278, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [PMID: 9520380].
Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW.
Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 95 3413-8 1998
Signatures from InterPro member databases are used to construct an entry.