Sodium/potassium/calcium exchanger 1 (IPR004817)

Short name: SLC24A1

Overlapping homologous superfamilies


Family relationships


Sodium/potassium/calcium exchanger 1 (NCKX1), also known as SLC24A1, is an integral membrane protein that transports one calcium and one potassium ion in exchange for four sodium ions. It is expressed only in retinal rod photoreceptors. NCKX1 controls the calcium concentration of outer segments during light and darkness, and is a critical component of the visual transduction cascade [PMID: 8556771, PMID: 12899631, PMID: 14770312]. Light causes a rapid lowering of cytosolic free calcium caused by extrusion via this protein, which plays a key role in light adaptation.

GO terms

Biological Process

GO:0006816 calcium ion transport
GO:0007601 visual perception

Molecular Function

GO:0008273 calcium, potassium:sodium antiporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.