Family

UvrABC system, subunit B (IPR004807)

Short name: UvrB

Family relationships

None.

Description

The UvrABC repair system catalyses the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage [PMID: 12145219].

This entry represents the UvrB subunit.

GO terms

Biological Process

GO:0006281 DNA repair
GO:0009432 SOS response
GO:0006289 nucleotide-excision repair

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0009381 excinuclease ABC activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PANTHER
HAMAP