Periplasmic protein thiol:disulphide oxidoreductase DsbE (IPR004799)

Short name: Periplasmic_diS_OxRdtase_DsbE

Overlapping homologous superfamilies

Family relationships



Periplasmic protein thiol:disulphide oxidoreductase is involved in the biogenesis of c-type cytochromes [PMID: 12196152] as well as in disulphide bond formation in some periplasmic proteins. This group defines the DsbE (also known as CcmG and CycY) subfamily. DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif [PMID: 12121652] that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c maturation (Ccm) factor with a redox active CXXC motif [PMID: 11843181]. Assembly of cytochrome c requires the ligation of heme to reduced thiols of the apocytochrome. In bacteria, this assembly occurs in the periplasm. The reductase activity of DsbE in the oxidizing environment of the periplasm is crucial in the maturation of cytochrome c [PMID: 11256948, PMID: 9537397].

GO terms

Biological Process

GO:0017004 cytochrome complex assembly

Molecular Function

GO:0015036 disulfide oxidoreductase activity

Cellular Component

GO:0030288 outer membrane-bounded periplasmic space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.