Pathways & interactions
Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA (IPR004763)
Short name: CzcA/CusA/SilA/NccA/HelA/CnrA
Overlapping homologous superfamilies
- Acriflavin resistance protein (IPR001036)
- Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA (IPR004763)
This family consists of the H+/heavy metal cation antiporters.
CzcA has a low cation transport activity for cobalt and is essential for the expression of cobalt, zinc and cadmium resistance.
NccA is a component of the NCC cation-efflux system that confers resistance to nickel, cobalt and cadmium. It may form a membrane tunnel, which allows ion transport across the membrane.
SilA is a component of the sil cation-efflux system that confers resistance to silver. It may be part of a three-component cation/proton antiporter.
HelA is presumed to function with HelC and HelB in efflux of an unidentified substrate.
The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
- TIGR00914 (2A0601)