Major facilitator superfamily, aromatic acid:H+ symporter family (IPR004746)

Short name: MFS_AAHS

Overlapping homologous superfamilies

Family relationships


The aromatic acid:H+ symporter family (AAHS) is classified as family 15 of the major facilitator superfamily (MFS) [PMID: 9529885]. Members of the AAHS family show fairly uniform sizes (418 to 460 residues). They transport a variety of aromatic acids as well as cis,cis-muconate [PMID: 9294455]. 4-hydroxybenzoate transporter (PcaK Ppu), a member of this family, has been implicated in chemotaxis, allowing the bacteria to swim up concentration gradients of its substrates [PMID: 7961399]. This is the only documented case where an MFS protein apparently serves as a chemoreceptor. One of the AAHS proteins (BenK Aca) transports benzoate [PMID: 9294456]. Under the transporter classification (TC) system [PMID: 10839820], this family is classified as TC number 2.A.1.15.

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.