GMP synthase, glutamine amidotransferase (IPR004739)

Short name: GMP_synth_GATase

Overlapping homologous superfamilies

Domain relationships


This signature represents the type 1 glutamine amidotransferase (GATase1) domain found in the N-terminal region of GMP synthase EC: GMP synthase catalyzes the synthesis of GMP from XMP [PMID: 6086650], [PMID: 3298209]. ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate

GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. It belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site [PMID: 8548458].

Glutamine amidotransferase (GATase) activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate.

GO terms

Biological Process

GO:0006177 GMP biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.