Transaldolase type 1 (IPR004730)

Short name: Transaldolase_1

Overlapping homologous superfamilies

Family relationships


Transaldolase (EC: catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34 kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated [PMID: 8109173] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.

This entry represents trasnaldolase type 1, which is found in bacteria, metazoa and fungi. The enzyme is found in the non-oxidative branch of the pentose phosphate pathway and forms a dimer in solution [PMID: 9343352].

GO terms

Biological Process

GO:0006098 pentose-phosphate shunt

Molecular Function

GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.