Translocation protein Sec62 (IPR004728)

Short name: Sec62

Overlapping homologous superfamilies


Family relationships


Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030176 integral component of endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.