Pathways & interactions
Short name: Deg-1
Overlapping homologous superfamilies
- Epithelial sodium channel (IPR001873)
- Degenerin (IPR004726)
The Caenorhabditis elegans mec-4 gene encodes a subunit of a candidate mechano-sensitive ion channel that plays a critical role in touch reception [PMID: 8655580]. The product is a mechano-sensory protein (degenerin). At least some of the proteins in this group form part of a mechano-transducing complex for touch sensitivity. Others include the acid-sensing ion channels, ASIC1-3 that are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. Mammalian ENaC (IPR004724) is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, have been shown to assemble to form the highly Na+-selective channel.
- TIGR00867 (deg-1)