Degenerin (IPR004726)

Short name: Deg-1

Overlapping homologous superfamilies


Family relationships


The Caenorhabditis elegans mec-4 gene encodes a subunit of a candidate mechano-sensitive ion channel that plays a critical role in touch reception [PMID: 8655580]. The product is a mechano-sensory protein (degenerin). At least some of the proteins in this group form part of a mechano-transducing complex for touch sensitivity. Others include the acid-sensing ion channels, ASIC1-3 that are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. Mammalian ENaC (IPR004724) is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, have been shown to assemble to form the highly Na+-selective channel.

GO terms

Biological Process

GO:0006811 ion transport

Molecular Function

GO:0005216 ion channel activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.