Phosphotransferase system, mannitol-specific enzyme IIC (IPR004718)

Short name: PTS_IIC_mtl

Overlapping homologous superfamilies


Domain relationships


Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families.

  • It is the only PTS family in which members possess a IID protein.
  • It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue.
  • Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars.
  • The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities.The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family.

    This group is specific for the IIC domain of the mannitol PTS transporters.

    GO terms

    Biological Process

    GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

    Molecular Function

    GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

    Cellular Component

    GO:0016021 integral component of membrane

    Contributing signatures

    Signatures from InterPro member databases are used to construct an entry.