Family

Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit (IPR004700)

Short name: PTS_IIC_man

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Mannose (Man) family is unique in several respects among PTS permease families [PMID: 15667312].

  • It is the only PTS family in which members possess a IID protein.
  • It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue.
  • Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars.

The mannose permease of Escherichia coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine.

This entry represents the IIC subunits of this family of PTS transporters.

GO terms

Biological Process

GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
TIGRFAMs
Pfam