Phosphotransferase system, enzyme II sorbitol-specific factor (IPR004699)

Short name: PTS_IID_sorb

Overlapping homologous superfamilies


Family relationships



Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families.

  • It is the only PTS family in which members possess a IID protein.
  • It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue.
  • Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars.
  • The Gut family consists only of glucitol-specific transporters, but these occur both in Gram-negative and Gram-positive bacteria. Escherichia coli consists of IIA protein, a IIC protein and a IIBC protein.

    This family is specific for the IIC component.

    GO terms

    Biological Process

    GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

    Molecular Function

    No terms assigned in this category.

    Cellular Component

    GO:0016021 integral component of membrane

    Contributing signatures

    Signatures from InterPro member databases are used to construct an entry.
    PROSITE profiles