Voltage-dependent anion channel (IPR004695)

Short name: Voltage-dep_anion_channel

Overlapping homologous superfamilies

Family relationships


Each of these transporters has ten alpha helical transmembrane segments [PMID: 20981093]. The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 (P50537) from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 (P41930) from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA (P25396) from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, homologues are found in the stomatal guard cells functioning as an anion-transporting pore [PMID: 18305484]. Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.