2-hydroxycarboxylate transporter (IPR004679)

Short name: 2-OHcarboxylate_transport

Overlapping homologous superfamilies


Family relationships


The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate [PMID: 16339740].

The majority of proteins in this family are known or predicted members of the citrate:cation symporter (CCS) family. They contain the predicted twelve-transmembrane helix motif common to many secondary transporters [PMID: 8810332]. Most of the characterised proteins in this entry are specific for citrate, with either Na+ of H+ as the contransported cation. However, one member is capable of cotransporting either citrate or malate with H+ [PMID: 11566984], while another has been shown to be an Na+-dependent malate cotransporter [PMID: 12949159].

GO terms

Biological Process

GO:0015711 organic anion transport

Molecular Function

GO:0008514 organic anion transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.